Saartok T Dahlberg E Gustafsson JA. Woodhouse LJ Gupta N Bhasin M Singh AB Ross R Phillips J Bhasin S. Dose-dependent effects of testosterone on regional mk-2866 sarms s4 gains adipose tissue distribution in healthy young men.
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For example if the goal was to promote bone growth in elderly men with osteoporosis while at the same time not stimulating the testes and prostate a SARM targeting bone and muscle tissue but with lesser activity on the prostate or testes would be far more suitable than testosterone treatment. Likewise if the goal was to stimulate libido and other sexual function in women while at the same time not causing the negative side-effects such as development of male characteristics (virilization) SARMs would be the way to do it. The first trial demonstrated effectiveness in 2003. There are currently a number of those which are of great interest to the bodybuilding community.
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A first generation selective estrogen receptor modulator (SERM). Like TAMOXIFEN it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites.
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