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Dr Carragee reports travel support from the US Army grants from the Orthopaedic Research and Education Foundation and AOSpine and options from Simpirica and Intrinsic Orthopedics. No other disclosures were reported. This study was mk-2866 sarms for bodybuilding supported by grant R01 AR053960 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the US National Institutes of Health to Drs Goldberg and Avins.
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The in-vivo efficacy and acute toxicity of four novel nonsteroidal androgens (compounds IV V VI and VII) in rats was examined. In-vitro assays established that these compounds bind the androgen receptor with very high affinity. The S-isomers of compounds GTx-014 (compound IV) GTx-015 (compound V) GTx-016 (compound VI) and GTx-007 (compound VII wherein R is NHCOCH3) and the R-isomer of GTx-014 were synthesized in accordance with the scheme as set forth in FIG. Sigma Chemical Company (St Louis Mo. Alzet osmotic pumps (model 2002) were purchased from Alza Corp. Palo Alto Calif.