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In these cases if the dose used physiological (normal) of hormones no difference occurs because there is a control mechanism that suppresses the normal production of the gland when the individual is using external hormone. For this reason the hormones prescribed in these situations and is not indicated by the lack of evidence that benefits outweigh the risks are being used in doses much higher than the physiological. This although initially it may cause positive results which encourage the individual to maintain its use usually has disastrous consequences.
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This industry traces its roots to a 1990 New England Journal of Medicine study in which 12 men over age 60 were given shots of growth hormone. The men experienced a modest increase in muscle mass and bone density and a decline in body fat. But the treatment came with side effects and myriad unknowns.
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