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SARMs maintain the beneficial effects of buy ostarine joint pain androgens on bone and muscle while reducing unwanted side effects. NEP28 is a new SARM exhibiting high Ostarine Researchsarms Gtx-024 selectivity for androgen receptor. To investigate the pharmacological effects of NEP28 we compared the effects on muscle prostate and brain with mice that were androgen depleted by orchidectomy and then treated with either placebo NEP28 dihydrotestosterone or methyltestosterone. We demonstrated that NEP28 showed tissue-selective effect equivalent to or higher than existing SARMs.
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We demonstrated that LGD2226 is fully active in cell-based models of bone and muscle. LGD2226 exhibited anabolic activity on muscle and bone with reduced impact on prostate growth in rodent models. Biomechanical testing of bones from animals treated with LGD2226 showed strong enhancement of bone strength above sham levels. LGD2226 was also efficacious Ostarine Researchsarms Gtx-024 Ostarine Researchsarms Gtx-024 in a sex-behavior model in male rats measuring mounts intromissions ejaculations and copulation efficiency. These results with an orally available nonaromatizable androgen demonstrate the important role of the AR and androgens in mediating a number of beneficial effects in bone muscle and sexual function independent from the conversion of androgens into estrogenic ligands. Taken
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together these results suggest that orally active nonsteroidal selective androgen receptor modulators may be useful therapeutics for enhancing muscle bone and sexual function.European Community from 1 May 2004 Ostarine Researchsarms Gtx-024 onwards. GSK is ultimately responsible for all aspects of the study even if some or all of these activities are transferred to another party.